Ok, cool, so far I understand that stuff.

I have learned something interesting in the meantime: The main driver for cancer is stress. So maybe ending your stressful relationship might reduce the risk of more cancer for both of you dramatically.

However if you no longer trust your wife, there is actually no point in continuing this. I get your point of being able to afford the divorce, but it actually does not really make sense.

I don't know in which jurisdiction you live, but in most western countries you basically split up what you have gathered during your marriage. So the longer you remain married the more there is to split up.

I guess the crucial point might be some kind of real estate, a house, a flat etc. which you can only pay off together?

In my opinion it is the much better option to divorce, get rid of that house/flat and live a happy life. This might feel like a financial loss, but in the end your career will be steeper if you are focused on your job and not your frustation at home, earning your more money in the end.

Furthermore I don't think that you can basically lose out if you bought real estate like 5 years ago, it is now worth much more, even if debt is not paid off, so selling it, paying off the debt and getting out of this with a profit is likely. You might have emotional attachment to that real estate and want to buy out your wife and so on and so forth, but that is the cornerstone of insanely bad investment decisions. You can trust me here, I don't have to work anymore, because my investment decisions were nice in the past (hopefully stay like that :D) and one thing I can tell you:

Emotional attachments are the worst thing for good decisions and nice financial outcomes. The second worst is delaying decisions. Or basically delaying action after a decision has been made.

My wife wanted to get a flat in the city. Fine. I'm not a fan, I prefer to live in an awesome house in a village, with less noise, less people, more nature. However back at that time, I just thought, well, she wants a flat in the city, this is the better investment, easier to sell, easier to rent out and less trouble to maintain, so I can focus on getting financially independent. So we bought a flat in a city and 5 years later I convinced her, that we should move out to the country side, bought a farmstead, nice and now we also have a flat in the city that is easy to rent out. Why was this possible? No emotional attachments. I just picked the option that has the best flexibility, even though not my emotional optimum.

Don't delay your decisions, it's an uphill battle, even though its going down constantly ;-)